White Cell Enzymes


Test Information

Test Name

White Cell Enzymes

Synonyms

WC Lysosomal Enzyme, Arylsulphatase A

Preferred Specimen

EDTA x 3 (whole blood)

Testing Location

Referral

Turn Around Time

8 weeks


Collection Information

Main Lab Only

Yes

Preparation

  • Micro collects are unsuitable
  • BOP/ WHK/ROT: Mon- Thurs collection only. Must be at lab before 4pm
  • TPO: Mon- Wed Collection only. Must be at lab before 9am.

Processing Information

Registration Code

WCL

Notes

  • DO NOT centrifuge; whole blood required
  • DO NOT refrigerate/freeze
  • DO NOT share sample; dedicated tubes required
  • Whole blood must be transported at room temperature

From LabPlus website:

White cell enzymes are used to diagnose children with suspected lysosomal disease. In general the cost for a screen is only slightly more than the cost of one particular enzyme. By ordering 'white cell enzymes' the following enzymes (diseases) are analysed:

  • beta-galactosidase (GM1-gangliosidosis)
  • beta-hexosaminidase A (Tay-Sachs disease)
  • total hexosaminidase A (Sandhoff disease)
  • arylsulphatase A (metachromatic leucodystrophy)
  • Glucosylsphingosine (Gaucher disease)
  • beta-galactocerebrosidase (Krabbe disease)
  • sphingomyelinase (Niemann-Pick disease types A & B)
  • alpha-fucosidase (Fucosidosis)
  • alpha-mannosidase (Mannosidosis)
  • acid lipase (Wolman's disease)
  • plasma alpha-N-acetylgalactosaminidase and alpha-mannosidase (I-cell disease, mucolipidosis type III and Schindler's disease)
  • palmitoyl-protein thioesterase I (Neuronal Ceroid Lipofuscinosis, NCL1), (infantile Batten disease)
  • tripeptidyl peptidase I (Neuronal Ceroid Lipofuscinosis, NCL2), (late infantile Batten disease).

Note: If you suspect a mucopolysaccharidosis (MPS) then the screening test of choice is urine mucopolysaccharides (GAGs)

Site Specific Notes

- Waikato

Refer patient to Waikato Hospital Laboratory between 1000-1230.

- Tauranga

Send directly to referral laboratory (LabPlus). Phone 0800 522 7587 ext 22016


Methodology

Interpretations

View Interpretations

Contact Information

laura.yau@pathlab.co.nz

External Referral Information

Referral Location

LabPlus (via WHL)

Send Away Notes

Notify Waikato Hospital Laboratory prior to sending sample

Send Away Volume

3mL

Send Away Transport

Ambient

External Lab Website