White Cell Enzymes


Test Information

Test Name

White Cell Enzymes

Synonyms

WC Lysosomal Enzyme, Arylsulphatase A

Preferred Specimen

EDTA x 3 (whole blood)

Testing Location

Referral

Turn Around Time

8 weeks


Collection Information

Main Lab Only

Yes

Availability

BOP/ WHK/ROT: Mon- Thurs collection only. Requests must be at lab before 4pm; TPO: Mon - Wed collection only. Must be at lab before 9am.

Preparation

  • Micro collects are unsuitable

Processing Information

Registration Code

WCL

Notes

  • DO NOT centrifuge; whole blood required
  • DO NOT refrigerate/freeze
  • DO NOT share sample; dedicated tubes required
  • Whole blood must be transported at room temperature

From LabPlus website:

White cell enzymes are used to diagnose children with suspected lysosomal disease. In general the cost for a screen is only slightly more than the cost of one particular enzyme. By ordering 'white cell enzymes' the following enzymes (diseases) are analysed:

  • beta-galactosidase (GM1-gangliosidosis)
  • beta-hexosaminidase A (Tay-Sachs disease)
  • total hexosaminidase A (Sandhoff disease)
  • arylsulphatase A (metachromatic leucodystrophy)
  • Glucosylsphingosine (Gaucher disease)
  • beta-galactocerebrosidase (Krabbe disease)
  • sphingomyelinase (Niemann-Pick disease types A & B)
  • alpha-fucosidase (Fucosidosis)
  • alpha-mannosidase (Mannosidosis)
  • acid lipase (Wolman's disease)
  • plasma alpha-N-acetylgalactosaminidase and alpha-mannosidase (I-cell disease, mucolipidosis type III and Schindler's disease)
  • palmitoyl-protein thioesterase I (Neuronal Ceroid Lipofuscinosis, NCL1), (infantile Batten disease)
  • tripeptidyl peptidase I (Neuronal Ceroid Lipofuscinosis, NCL2), (late infantile Batten disease).

Note: If you suspect a mucopolysaccharidosis (MPS) then the screening test of choice is urine mucopolysaccharides (GAGs)

Site Specific Notes

- Waikato

Refer patient to Waikato Hospital Laboratory between 1000-1230.

- Tauranga

Send directly to referral laboratory. AM requests send to LabPlus; PM requests send to Canterbury Health Laboratory. Phone 0800 843 522 ext. 80118 before sending to ensure samples are prepared within 18 hours of collection.


Methodology

Interpretations

View Interpretations

Contact Information

laura.yau@pathlab.co.nz

External Referral Information

Referral Location

LabPlus (via WHL)

Send Away Notes

Notify Waikato Hospital Laboratory prior to sending sample

Send Away Transport

Ambient

External Lab Website